Impact of SARS-CoV-2 Infection During Pregnancy on Newborns and Young Children
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pregnancy
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
- Enrollment
- 1362
- Locations
- 1
- Primary Endpoint
- Outcome of pregnancy
- Status
- Terminated
- Last Updated
- last year
Overview
Brief Summary
This study aim is to assess impact of COVID-19 infection during pregnancy on outcome of pregnancy, and on developement of the child in early life.
Detailed Description
All pregnant women will be tested for serology during each trimester of pregnancy and at delivery, together with a nasal swab. Children born to women with positive sawb or serology will be followed up for 3 years together with a control child born to negative mother. In positive mothers, maternal antibodies at delivery will be characterized, placental transfer will be assessed. Persistence of antibodies in children at the age of 1 month and presence of antibodies in breast milk will be measured. Occurence of premature birth, low birth weight, miscarriage, congenital malformations will be compared in positive and negative mothers. Follow up of children over the first 3 years of life will assess difference in susceptibility to infections and neurological developement in both groups.
Investigators
Eligibility Criteria
Inclusion Criteria
- •For pregnant women, all women who deliver in the CHU St Pierre, with oral consent.
- •For children follow up: children born to positive mothers and matched controls after written consent
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Outcome of pregnancy
Time Frame: Up to the delivery
Incidence of miscarriage, premature delivery, low birth weight, preeclampsia, chorioamnionitis
Secondary Outcomes
- Prevalence of positive serology to SARS-CoV-2 at delivery(At the delivery)
- Presence of maternal antibodies to SARS-CoV-2 in breast milk in breastfeeding mothers(At 1 month post delivery)
- To characterize the immunity transmitted to the newborn to cord blood and its persistence at the age of 1 month of life(Up to 1 month post delivery)
- Clinical evolution of the children(Up to 3 years)
- To characterize placental alterations related to SARS-CoV-2 infection(At the delivery)
- Transplacental transfer of antibodies to SARS-CoV-2(At the delivery)