Effect of COVID-19 Infection on Obstertric Complications and Maternal Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 260
- 试验地点
- 1
- 主要终点
- Pregnancy related complications
研究概览
简要总结
This study aimed to evaluate the effect of COVID-19 infection on obstetric complications and maternal outcomes.
详细描述
During the SARS-CoV-2 pandemic, pregnant women were reported to have a higher susceptibility to COVID-19 infection. Pregnant women who tested positive for SARS-CoV-2 are at higher risk of a severe form of COVID-19, associated with higher rates of intensive care unit (ICU) admission and increased needs for respiratory support, compared to the age-matched non-pregnant population.
Women infected during pregnancy also have an increased risk of adverse pregnancy outcomes including preterm-birth, with a significant proportion secondary to iatrogenic preterm birth due to maternal illness. Infection with SARS-CoV-2 during pregnancy has also been reported to be associated with a higher risk of stillbirth directly or indirectly caused by the virus.
Infected pregnant patients tended to present asymptomatically with pre-Delta and Omicron variants, and symptomatically with Delta variant. A previous systematic review suggested that people who are pregnant did not have an increased risk of SARS-CoV-2 infection or symptomatic COVID-19, but they were at risk of severe COVID-19 compared with those who were not pregnant.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age from 18 to 40 years.
- •Pregnant women with COVID-19 infection diagnosed either by PCR or rapid test.
排除标准
- •Patients vaccinated for COVID-19 before or during the current pregnancy.
结局指标
主要结局
Pregnancy related complications
时间窗: For one month
Pregnancy related complications as preterm birth, preeclampsia, intrauterine fetal demise (IUFD), increased cesarean section rate, postpartum hemorrhagic gastroenteritis (HGE) were collected
次要结局
- Apgar score(For 5 minutes post-intervention)
- Intensive care unit admission rate(For one month)
- Use of mechanical ventilation(For one year)
- Incidence of death(For one month)
研究者
Mai Nabil Ageez
Lecturer of Obstetrics and Gynecology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University