Interference With Cognitive Control by Transcranial Direct Current Stimulation
- Conditions
- Depression
- Interventions
- Device: Cathodal transcranial direct current stimulation (tDCS)Device: Sham transcranial direct current stimulation
- Registration Number
- NCT01903538
- Lead Sponsor
- University Hospital Tuebingen
- Brief Summary
Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit. In this study the investigators assess the effect of a decrease of dlPFC activity in healthy subjects by cathodal transcranial direct current stimulation (tDCS) on cognitive control.
In a double-blinded, balanced randomized, sham-controlled crossover trial the investigators determine the effect of a single-session of cathodal tDCS to the left dlPFC on cognitive control in healthy subjects. To assess the cognitive control the investigators use a delayed response working memory task (DWM)and an arithmetic inhibition task (AIT) with pictures of varying valence.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 28
informed consent
psychiatric or neurological disorders seizures cardiac pacemakers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Cathodal transcranial direct current stimulation Cathodal transcranial direct current stimulation (tDCS) - Sham transcranial direct current stimulation Sham transcranial direct current stimulation -
- Primary Outcome Measures
Name Time Method Correctness and reaction time of response Within 30 min starting 5 min after the initiation of stimulation Correctness is defined as the percentage of correct responses in the DWM and AIT
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Psychiatry and Psychotherapy, University of Tübingen
🇩🇪Tübingen, Germany