Interference With Cognitive Control by Transcranial Direct Current Stimulation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Depression
- Sponsor
- University Hospital Tuebingen
- Enrollment
- 28
- Locations
- 1
- Primary Endpoint
- Correctness and reaction time of response
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit. In this study the investigators assess the effect of a decrease of dlPFC activity in healthy subjects by cathodal transcranial direct current stimulation (tDCS) on cognitive control.
In a double-blinded, balanced randomized, sham-controlled crossover trial the investigators determine the effect of a single-session of cathodal tDCS to the left dlPFC on cognitive control in healthy subjects. To assess the cognitive control the investigators use a delayed response working memory task (DWM)and an arithmetic inhibition task (AIT) with pictures of varying valence.
Investigators
Christian Plewnia, MD
Professor
University Hospital Tuebingen
Eligibility Criteria
Inclusion Criteria
- •informed consent
Exclusion Criteria
- •psychiatric or neurological disorders seizures cardiac pacemakers
Outcomes
Primary Outcomes
Correctness and reaction time of response
Time Frame: Within 30 min starting 5 min after the initiation of stimulation
Correctness is defined as the percentage of correct responses in the DWM and AIT