Modulation of Cognitive Control in Healthy and Depressed Subjects by Transcranial Direct Current Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Correctness of response
研究概览
简要总结
Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit. In this study the investigators assess the effect of an enhancement of dlPFC activity in MDD patients by anodal transcranial direct current stimulation (tDCS) on cognitive control.
In a double-blinded, balanced randomized, sham-controlled crossover trial the investigators determine the effect of a single-session tDCS to the left dlPFC on cognitive control in MDD patients and healthy controls. To assess the cognitive control the investigators use a delayed response working memory (DWM) task with pictures of varying valence presented during the delay period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age > 18
- •informed consent
- •in the patients group: Major depressive disorder, no antidepressant medication or stability over 1 week
排除标准
- •cardiac pacemaker
- •deep brain stimulation
结局指标
主要结局
Correctness of response
时间窗: The primary outcome measure is obtained during the intervention (20min tDCS or sham stimulation).
次要结局
- Reaction time(The secondary outcome measure is obtained during the intervention (20min tDCS or sham stimulation).)
研究者
Christian Plewnia, MD
Professer
University Hospital Tuebingen