Modulation of Cognitive Control in Healthy and Depressed Subjects by Transcranial Direct Current Stimulation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Major Depression
- Sponsor
- University Hospital Tuebingen
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- Correctness of response
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit. In this study the investigators assess the effect of an enhancement of dlPFC activity in MDD patients by anodal transcranial direct current stimulation (tDCS) on cognitive control.
In a double-blinded, balanced randomized, sham-controlled crossover trial the investigators determine the effect of a single-session tDCS to the left dlPFC on cognitive control in MDD patients and healthy controls. To assess the cognitive control the investigators use a delayed response working memory (DWM) task with pictures of varying valence presented during the delay period.
Investigators
Christian Plewnia, MD
Professer
University Hospital Tuebingen
Eligibility Criteria
Inclusion Criteria
- •age \> 18
- •informed consent
- •in the patients group: Major depressive disorder, no antidepressant medication or stability over 1 week
Exclusion Criteria
- •cardiac pacemaker
- •deep brain stimulation
Outcomes
Primary Outcomes
Correctness of response
Time Frame: The primary outcome measure is obtained during the intervention (20min tDCS or sham stimulation).
Secondary Outcomes
- Reaction time(The secondary outcome measure is obtained during the intervention (20min tDCS or sham stimulation).)