Ultrasound Guided Thoracic Paravertebral Block for Hepatic Tumors Ablation

Not Applicable

Completed

• Conditions: Liver Cancer
• Interventions: Drug: 0.5% marcaine 20ml

• Registration Number: NCT02271646
• Lead Sponsor: Mahidol University

Brief Summary

Patients undergo percutaneous radiofrequency ablation of hepatic tumors at Siriraj hospital normally receive only intravenous sedative drugs which sometimes can not provide effective pain control.

TPVB is suitable for unilateral operations. And it is increasing popular nowadays because of using ultrasound guided which make it is more reliable and has less side effects especially the severe one such as pneumothorax. To cover all nerve supply liver, we decided to use right TPVB at T5-6, T7-8, and T9-10.

The aim of this study is to prove that TPVB can provide an effective pain control for patients undergo liver RFA both at rest and movement (cough). We are going to measure the pain score at recovery room and the effective pain control means patients has mild pain (pain score less \</= 3 and do not ask for analgesic drugs).

Detailed Description

Not available

Study Timeline

• Study Start: 2014-08
• Study First Submitted: 2014-09-03
• Study First Submitted QC: 2014-10-20
• Study First Posted: 2014-10-22
• Primary Completion: 2015-03
• Study Completion: 2015-03
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-10
• Last Update Posted: 2019-03-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• Age > 18 years
• Patients undergo percutaneous radiofrequency ablation for liver tumors
• ASA classification 1-3

Exclusion Criteria

• Psychiatric illness
• Chronic abdominal pain > 1 week
• Regular analgesic drugs use
• Infection at back (Block area)
• Severe spinal deformity
• PT > 16 sec, aPTT > 32, platelet < 50,000/cumm

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
0.5% marcaine 20ml	0.5% marcaine 20ml	3 levels ultrasound guided thoracic paravertebral blocks at T5-6, T7-8 and T9-10 (total 0.5% marcaine 20ml)

Primary Outcome Measures

Name	Time	Method
pain score at recovery room both at rest and movement (cough)	Up to 24 hours	All patients at recovery room has mild pain (pain score \</= 3) and do not need any rescue analgesic drugs.

Secondary Outcome Measures

Name	Time	Method
Distribution of local anesthetic drugs after performing ultrasound guided TPVB at T5-6, T7-8 and T9-10.	After performing TPVB at 5, 10, 20 and 30 minutes.	Test with cold sensation.

Trial Locations

Locations (1)

Siriraj hospital; 🇹🇭 Bangkok, Thailand