Prospective study for evaluating coronary microvascular dysfunction in patients with vasospastic angina
Not Applicable
- Conditions
- vasospastic angina
- Registration Number
- JPRN-UMIN000019863
- Lead Sponsor
- Chiba University Hospital, Department of Cardiovascular Medicine
- Brief Summary
Patients with VSA had a significantly lower reactive hyperemia index compared with those without VSA. Coronary flow reserve, index of microcirculatory resistance, and hyperemic Tmn were not different between the two groups, whereas resting Tmn was significantly longer in patients with VSA. Although the frequency and severity of angina improved from baseline to 1 and 3 months in patients with both positive and negative ACh tests, there was no difference between the two groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
1) Patients with hemodialysis 2) Patients with severe hepatic disorder 3) Patients with severe heart failure (ejection fraction <30% or NYHA >class 3) 4) Patients with prior coronary intervention for left anterior descending artery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of the index of microcirculatory resistance (IMR) between patients with positive acetylcholine (ACh) provocation test and those with negative
- Secondary Outcome Measures
Name Time Method 1) Coronary flow reserve (CFR) in patients with positive or negative ACh provocation test 2) Relation between chest symptom and IMR or CFR 3) Relation between IMR or CFR and chest symptom in patients with negative ACh provocation test 4) IMR, CFR and mean transit time (MTT) which indicate coronary epicardial or microvascular spasm 5) Relation between reactive hyperemia index (RHI) and IMR, CFR, MTT, or positivity of ACh provocation test 6) Relation between RHI and chest symptom