Sleep-like activity in peritumoral brain areas measured with TMS-EEG

Recruiting

• Conditions: C71; Malignant neoplasm of brain

• Registration Number: DRKS00030821
• Lead Sponsor: Klinik für Neurochirurgie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-12-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

Age above 18 years, Written informed consent; Only patients: Suspected brain tumor after MRI, Participation in TMS measurement

Exclusion Criteria

Contraindications for receiving an MRI, Contraindications for receiving a TMS measurement, More than one generalized seizure per week, Pregnancy, Missing conset to participate in the study; Only healthy controls: History of psychiatric or neurological diseases

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Amplitude of low-frequency TEP-components (< 4Hz) 8-350ms after the TMS pulse

Secondary Outcome Measures

Name	Time	Method
Power of high-frequency EEG components (>20Hz) 150-350ms after the TMS pulse;<br>Local and global signal complexity measured as PCIst;<br>Resting-state power spectral density of the 4 EEG-electrodes around the respective stimulation sites;<br>Number of deflections in the EEG signal;<br>Motor status measured with the BMRC for upper and lower extremities;<br>Finger tapping score;<br>Time required to perform the 9-hole peg test;<br>Aachener Aphasie Test Score;<br>Montreal-Cognitive Assessment Test Score