Functional MRI during Sleep in Patients with Posttraumatic Stress Disorder

Completed

• Conditions: psychotrauma; traumatic stress; 10040998; 10002861

• Registration Number: NL-OMON31936
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 18

Inclusion Criteria

- PTSD diagnosed by DSM-IV criteria, and confirmed by a diagnostic interview (SCID) (only for patients)
- CAPS score > 50 (only for patients)
- Male
- Age between 18 and 60 years
- Exposure to deployment based traumatic stress

Exclusion Criteria

- Antidepressant usage within 2 months prior to the start of the study
- Usage of any other psychotropic medication within 4 weeks prior to the start of the study
- History of psychiatric disease (controls), neurological illness (all subjects), of systemic disease (all subjects)
- Sleep disturbed breathing or periodic limb movement disorder
- History of alcohol and/or drug abuse (DSM-IV criteria) within 6 months prior to the study
- Metal objects in or around the body (braces, pacemaker, etc)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Activation of hippocampus and prefrontal cortex during sleep spindles in PTSD<br /><br>subjects as compared with healthy veterans. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The correlation between delayed recall of the 15 word test and activation of<br /><br>hippocampus and prefrontal cortex during sleep spindles. </p><br>