An fMRI and EEG study in patients with mild to moderate Alzheimer’s disease and healthy elderly controls
- Conditions
- Alzheimer's disease, healthy volunteers, biomarker
- Registration Number
- NL-OMON21111
- Lead Sponsor
- Centre for Human Drug Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
All subjects:
1.Aged 50-75 years;
Exclusion Criteria
All subjects:
1.Any contra-indications for MRI (prostheses, implants, claustrophobia, pacemakers, etc.);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method fMRI memory task - BOLD activity<br /><br>fMRI perception task - BOLD activity<br /><br>EEG based technique to measure longterm potentiation- amplitudes and latencies<br /><br>auditory steady state response - gamma oscillations<br />
- Secondary Outcome Measures
Name Time Method fMRI resting state - default mode network<br /><br>Evoked related potentials - amplitude and latencies