Resting state functional MRI in term neonates with perinatal asphyxia

Completed

• Conditions: asphyxia; cerebral damage; 10029299; 10010335; 10028920

• Registration Number: NL-OMON44127
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-05-31
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 23

Inclusion Criteria

Term neonates clinically diagnosed with perinatal asphyxia.

Exclusion Criteria

Lack of informed consent of parents (parental refusal or unable to explain because of language barrier).
Neonate with known congenital malformation(s) of the brain or congenital infection of the brain.
Neonate with known syndrome (e.g. Down syndrome).
Neonate with known congenital neuromuscular disease.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1.Feasibility of the rs-fMRI technique will be determined by assessing the<br /><br>image quality of the dynamic scans, the presence of motion artefacts and the<br /><br>temporal SNR.<br /><br>2. The intra-session reproducibility of the rs-fMRI technique in neonates with<br /><br>asphyxia determined by the mean and Standard Deviation (SD) of the difference<br /><br>between 2 rs-fMRI acquisitions of 6 minutes each of the volume of the activated<br /><br>set of voxels and of the signal intensity of these voxels. Bland-Altman plots<br /><br>and Smallest Detectable Change will be used to report this.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nvt</p><br>