Study of brain damage in newborns with increased sodium levels
Phase 4
- Conditions
- Health Condition 1: N19- Unspecified kidney failure
- Registration Number
- CTRI/2019/06/019706
- Lead Sponsor
- Dr Anurag Singh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Neonates (0 to 28 days) admitted with hypernatremia (serum sodium level >150mEq/l) will be included.
Exclusion Criteria
Neonate with:
1. Congenital malformations.
2. Suspected metabolic disease
3. known case of structural renal disease/previously diagnosed kidney disease
4. History of delayed cry/hypoxic ischemic encephalopathy
5. Sepsis screen or blood culture positive
6. Coagulopathy
7. Previous admission
8. History of abortion or unexplained sibling death in maternal history
9. History of stroke, DVT, early age MI or thromboembolic phenomena in family
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To find out nature of intracranial pathology (brain lesion) in hypernatremic neonates and Correlation with clinical presentation and MRI brain <br/ ><br>Timepoint: Till 28 days of life
- Secondary Outcome Measures
Name Time Method To find out correlation between location, number and types of lesion and degree of hypernatremia. <br/ ><br>To find out incidence mri brain changes of hypernatremia in sick neonates admitted in NICU of Umaid hospital.Timepoint: Till 28 days of life.