Effects of Malnutrition on Respiratory and Renal Functions in Patients Undergoing Peroral Endoscopic Myotomy (POEM)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Esophageal Achalasia
- Sponsor
- Umraniye Education and Research Hospital
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- cardiorespiratory advers events
- Status
- Recruiting
- Last Updated
- 5 months ago
Overview
Brief Summary
The hypothesis of this study is to investigate cardiorespiratory and renal complications in patients under general anesthesia undergoing POEM surgery.
Detailed Description
The primary purpose of this study is to define mild, medium and severe risk groups for malnutrition by using preoperative albumin values and MUST score in achalasia patients planned for POEM operation, and to determine the relationship of malnutrition/degree as well as demographic characteristics and comorbidities with postoperative respiratory and renal complications. The secondary aim of this study was to determine persistent respiratory and renal outcome at 3 months after POEM procedure.
Investigators
Zeliha Alicikus
Chief Anesthesiologist
Umraniye Education and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •Criteria for inclusion in the study:
- •Patients diagnosed with achalasia and suitable for POEM treatment by gastroenterology physicians
- •Between the ages of 18-80
Exclusion Criteria
- •Criteria for exclusion from the study:
- •Those with a known history of active lung infection, advanced COPD, or respiratory failure
- •Patients with EF below 40%, severe ischemic heart failure, presence of valve disease
- •Those with bleeding diathesis and severe thrombocytopenia (limit 30-50 thousand)
- •severe kidney dysfunction
- •In the presence of known intolerance or allergy to certain medications for sedation, analgesia, or both
- •Pre-existing increased intracranial pressure
- •Having a BMI \>30
- •Severe uncorrected hypovolemiaHistory of radiotherapy to the esophagus
- •History of mucosal resection or ablation in the area where POEM will be applied
Outcomes
Primary Outcomes
cardiorespiratory advers events
Time Frame: up to 12 weeks
hypercapnia (above 45mmHg)
postoperative renal complications
Time Frame: up to 12 weeks
serum creatinine 0.3 mg/dL rise
Secondary Outcomes
- Malnutrition condition(up to 12 weeks)
- escart score(up to 12 weeks)