Very Small Embryonic-like Stem Cells for Ovary
- Conditions
- Stem Cell Transplant ComplicationsPremature Ovarian Failure
- Registration Number
- NCT03985462
- Lead Sponsor
- Fuda Cancer Hospital, Guangzhou
- Brief Summary
The aim of this study is the safety and efficacy of autologous very small embryonic-like stem cells(VSELs) to premature ovarian failure.
- Detailed Description
Premature ovarian failure is diagnosed by blood femal hormones test of follicle stimulating hormone (FSH, \> 40 IU/L)、luteinizing hormon (LH, \> 40 IU/L)、estradiol (E2, \> 100pg/mL) and/or amenorrhea before the age of 40. VSELs come from the patient's periperal blood, and will be injected in bilateral oviducts, followed-up by hormone testing and menstrual conditions.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- Female
- Target Recruitment
- Not specified
- Patients who are diagnosed as premature ovarian failure by professional doctor.
- Those have clear abnormal sex hormone levels
- Unmarried woman
- Suffering from other serious gynecological diseases or gynecological tumors
- Blood disease patients, thrombocytopenia or dysfunction, hypofibrinemia or anticoagulant therapy, long-term use of aspirin
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Concentration of Blood female hormones level 1 month after injection Check whether blood FSH, LH and E2 levels return to normal
- Secondary Outcome Measures
Name Time Method Incidence of amenorrhea 12 months after injection Inquire about menstrual condition and exam ovarian blood supply by gynecological color ultrasound
Concentration of Blood female hormones level 12 months after injection Check whether blood FSH, LH and E2 levels return to normal
Trial Locations
- Locations (1)
Biological treatment center in Fuda cancer hospital
🇨🇳Guangzhou, Guangdong, China
Biological treatment center in Fuda cancer hospital🇨🇳Guangzhou, Guangdong, China