Cardiovascular Risk Factors After Renal Transplantation in Children and Adults

• Conditions: Hypertension; Exercise Capacity; Metabolic Syndrome; Physical Activity; Overweight and Obesity

• Registration Number: NCT01008306
• Lead Sponsor: Oslo University Hospital

Brief Summary

Renal transplantation of children started in Norway in 1970.Since the beginning, \>80% of renal transplants are provided from Living Donors(mainly parents), short pre-transplant dialysis time( median 4 months) and 50% of transplantations are performed before dialysis is needed.This gives good premises for graft survival and avoidance of detrimental effects of dialysis. However, renal transplanted children are subjected to an increased cardiovascular morbidity and mortality in adulthood due to consequences of chronic renal failure and immunosuppressive treatment.Cardiovascular death comprises 30-40% of death causes. In this cross-sectional study we evaluate cardiovascular risk factors in childhood- and also in young adults renal transplanted in childhood.

Focus is cardiorespiratory fitness using treadmill testing,24h BP measurements, anthropometrics including waist circumference,echocardiography,intima media thickness of carotids, glucose intolerance test.Participants are also requested to fill out physical activity recalls and Quality of life questionnaires.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-06
• Status Verified: 2009-11
• Study First Submitted: 2009-11-03
• Study First Submitted QC: 2009-11-04
• Last Update Submitted: 2009-11-04
• Study First Posted: 2009-11-05
• Last Update Posted: 2009-11-05
• Primary Completion: 2010-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Transplanted after 1983, functioning graft

Exclusion Criteria

• Patients in dialysis
• In part of the study concerning treadmill testing: Age<8 years, orthopedic limitations

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Oslo University Hospital Rikshospitalet HF, Division of Pediatrics; 🇳🇴 Oslo, Norway