Renal Sympathectomy in dialysis-dependent patients to reduce cardiovascular risk. A pilot study

Not Applicable

Completed

• Conditions: End Stage Kidney Disease; Renal and Urogenital - Kidney disease; Cardiovascular - Other cardiovascular diseases; Cardiovascular - Hypertension

• Registration Number: ACTRN12613000562774
• Lead Sponsor: niversity of Otago

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-05-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Age > 18 and able to give consent.
On dialysis for at least 3 months.
Clinically stable with no evidence of fluid overload, recent myocardial ischaemia or heart attack.
Blood pressure > 130/90 despite medications.
They must have intact native renal kidneys

Exclusion Criteria

Patients with significant renovascular abnormalities will not permitted to undergo the intervention. Anatomic abnormalities including multiple main renal arteries, short length main renal arteries, failed renal transplant, are exclusion criteria.
Inability to give consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in renal sympathetic nerve activity as measured by multiunit sympathetic nerve activity[Baseline prior to the procedure, then at 1month, 3 months and 12 months after the procedure]

Secondary Outcome Measures

Name	Time	Method
Changes in cardiac function as assessed by beat to beat variability on holter monitoring, echocardiographic changes in left ventricular function and volume, and changes in blood pressure.[Baseline prior to the procedure and then at 1 month, 3 months, 12 months after the procedure]; Changes in circulating plasma catecholamines and beat to beat variability in heart rate as markers of systemic sympathetic activity after the intervention compared to baseline values.[Baseline prior to the procedure and at 1 month. 3 months, 12 months after the procedure.]