A study of the behavior of the lungs in critically ill patients to optimise treatment

Not Applicable

Completed

• Conditions: Acute lung injury (ALI); Acute respiratory distress syndrome (ARDS); Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12611001179921
• Lead Sponsor: niversity of Canterbury

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2011-08-31
• Study Start: 2011-11-14
• Last Update Posted: 21 July 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

All recruited participants have acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Patients with ALI have a P/F ratio 200-300 mmHg, and those with ARDS have a P/F ratio less than 200 mmHg. The P/F ratio is defined as the partial pressure of oxygen in the arterial blood divided by the fraction of inspired oxygen. The more severe the lung injury the lower this number.

Exclusion Criteria

1. Patients who are improving and likely to be discontinued from mechanical ventilation within 24 hours

2. Patients who are not expected to survive.

3. Patients who are minimally sedated but oriented in either time or place or person. These patients are excluded because they will require additional sedation or relaxants to participate, which may cause additional inconvenience and prolong their length of stay.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Observation of lung mechanics with the change of mechanical ventilation settings (PEEP change).[Continuous recording from the ventilator/ airway pressure and flow during recruitment maneuver.]

Secondary Outcome Measures

Name	Time	Method
Observation of Arterial blood gas information before and after recruitment maneuver.[Before recruitment maneuver and 30 minutes after recruitment maneuver.]