Genetic origin of Dupuytren*s disease and associated fibromatosis

Completed

Conditions: Dupuytren's disease
Ledderhose's disease
Peyronie's disease
10028396
10010761

Registration Number: NL-OMON30567

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 600

Inclusion Criteria

Gene expression study:
1.Clinically confirmed diagnosis of Dupuytren*s, Peyronie*s or Ledderhose*s disease
2.Patient for which selective fasciectomy or plaque excision/biopsy is part of standard treatment
3.Evident cord AND node at physical examination (only for patients with Dupuytren*s disease)
4. Age >= 18;Gene expression study Dupuytren controls:
1.Confirmed diagnosis of Carpal Tunnel Syndrome
2.Patient for which carpal tunnel release is part of standard treatment
3.Age >= 18;Gene expression study Peyronie controls:
1.Patient receiving penile prosthesis implants for erectile dysfunction or patient having penis amputation
2.Age >= 18;Pedigree analysis and association study:
1.Clinically confirmed diagnosis of Dupuytren*s disease, Peyronie*s disease or Ledderhose*s disease
2.Having relatives with one of these diseases (only for pedigree analysis)
3.Age >= 18;Pedigree analysis family of proband:
1. Age >= 18;Association study controls:
1.Age >= 18

Exclusion Criteria

Gene expression study:
1.Post-surgical recurrence
2.Patients unfit to undergo surgery;Gene expression study Dupuytren controls:
1.Diagnosis of Dupuytren*s, Peyronie*s or Ledderhose*s disease or a positive family history for one of these diseases;Gene expression study Peyronie controls:
1.Diagnosis of Dupuytren*s, Peyronie*s or Ledderhose*s disease or a positive family history for one of these diseases;Pedigree analysis and association study:
None;Pedigree analysis family of proband:
None;Association study controls:
1.Diagnosis of Dupuytren*s disease, Peyronie*s disease or Ledderhose*s disease or a positive family history for one of these diseases

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Finding the causative gene(s) of the different fibromatosis. Increasing<br /><br>understanding of the etiology/pathology of the diseases and there relation to<br /><br>each other. </p><br>

Secondary Outcome Measures