The influence of methylenetetrahydrofolate reductase C677T genotype and folate status on deoxyribonucleic acid methylation and uracil misincorporation in the colon of healthy volunteers

Not Applicable

Completed

• Conditions: Colorectal cancer; Cancer

• Registration Number: ISRCTN43577261
• Lead Sponsor: King's College London Nutritional Sciences Research Division

Brief Summary

2013 results in: http://www.ncbi.nlm.nih.gov/pubmed/24108782

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-10-06
• Study Completion: 2009-09-11
• Last Update Posted: 3 February 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

No lesions detected on full colonoscopy

Exclusion Criteria

1. Colorectal polyps or cancer discovered at present colonoscopy
2. Current or previous diagnosis of cancer, or a strong family history of colorectal cancer or adenomatous polyposis coli
3. Inflammatory bowel disease
4. Current or past history of gluten-sensitive enteropathy
5. Clinical and/or laboratory evidence of intestinal malabsorption
6. Significant renal or liver disease
7. Pregnancy
8. Epilepsy
9. Alcoholism
10. Pernicious anaemia
11. Serum vitamin B12 levels less than 180 ng/l and the use of medication known to antagonise the metabolism of folate

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in genomic and gene specific DNA methylation and uracil misincorporation.

Secondary Outcome Measures

Name	Time	Method
Changes in blood and tissue folate and plasma homocysteine.