Stem Cells for Treatment of Bronchopleural Fistula
- Conditions
- Bronchopleural Fistula
- Interventions
- Biological: UCMSC
- Registration Number
- NCT02961725
- Lead Sponsor
- The Second Affiliated Hospital of Fujian Medical University
- Brief Summary
Bronchopleural fistula (BF), an abnormal passage or communication between a bronchus and another part of the body, may develop when there are penetrating wounds of the thorax and after lung surgery. Without effective therapy, treatment of BF is a challenge, with a high rate of mortality and teratogenicity.
The investigators will conduct endoscopic injection of umbilical cord mesenchymal stem cells to fistula, observe the recovery of bronchopleural fistula and systemic reactions, to investigate the application of umbilical cord mesenchymal stem cells in the treatment of bronchopleural fistula.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10
- diagnosed with bronchopleural fistula by imaging or bronchoscopic examination
- typical symptom of bronchopleural fistula, such as fever, cough, purulent sputum, weight loss...
- patients present compromised conditions, who can only accept a conservative treatment.
- absolute contraindication of bronchoscopic examination and treatment
- with previous treatment of cell therapy, including stem cells.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description UCMSC treatment UCMSC UCMSC: umbilical cord mesenchymal stem cells
- Primary Outcome Measures
Name Time Method closure of the fistula 24 weeks median time for fistula closure
- Secondary Outcome Measures
Name Time Method complication 1 year fever, coughing up blood, infection...
Trial Locations
- Locations (1)
The Second Affiliated Hospital of Fujian Medical University
🇨🇳Quanzhou, Fujian, China