The effect of Comvita propolis supplementation on markers of immune function in healthy adults.

Not Applicable

• Conditions: Immune function; Inflammatory and Immune System - Normal development and function of the immune system

• Registration Number: ACTRN12623001247662
• Lead Sponsor: Dr Jocelyn Eason

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-12-01
• Last Update Posted: 12 December 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Participants will be included if they have given written informed consent and are gauged as healthy by self report and their General Health Questionnaire. Participants will be included if their blood parameters do not indicate significant illness for albumin, alkaline phosphatase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea, calcium, chloride, creatinine, potassium, sodium, total bilirubin, total protein, glucose, HbA1c.

Exclusion Criteria

Blood parameters for albumin, alkaline phosphatase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea, calcium, chloride, creatinine, potassium, sodium, total bilirubin, total protein, glucose and HBA1c being indicative of clinically significant illness. Participants will be excluded if they are unwilling to unable to provide written consent or comply with the study procedures. Participants will also be excluded if they have known hypersensitivity or intolerance to propolis bee stings and/or specific food additives. In addition, participants will be excluded if they are breastfeeding, pregnant, planning to get pregnant in the immediate future or have any of the following conditions: (i) blood borne diseases (e.g. hepatitis), (ii) recent bacterial or viral illness or (iii) are taking medication that affects the properties of blood (e.g. blood clotting).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Composite cytokine production of ex-vivo stimulated peripheral immune cells isolated from participants' peripheral blood.[Assayed using a bead-based multiplex assay kit and measured by flow cytometry. Pre-supplementation, 2 h after consuming the first dose (acute) and after 6 weeks supplementation.]