Comparsion Between Intrathecal Fentanyl and Intravenous Nalbuphine As a Postoperative Analgesia in Lower Limb Surgeries
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- first request of rescue analgesia
研究概览
简要总结
Postoperative pain management has been a major challenge and there has been great interest about it ., there have been persistent efforts to bring out the best possible analgesic technique with the least side effects. The popularity of lower limb surgeries owing to its higher incidence, orthopedic and vascular surgerise. Inadequate postoperative pain relief is associated with undesirable side effects resulting in chronic persistent pain, delayed recovery Concern about opioid has powerful effect in relief post operative pain.
the aim of this study is to Compare between fentanyl intrathecal and nalbuphine IV as a postoperative analgesia in lower limb surgeries
详细描述
Fentanyl, a potent lipid-soluble opioid which was first synthesized more than 40years ago, is still the most popular opioid used as post operative analgesia t. Fentanyl given intrathecally use in many acute and chronic pain conditions. inspite of its side effects fentanyl remains the mainstay of anesthesiologists in post operative period analgesia.
Anesthetic methods of Lower limb surgery such as orthopedic and vascular surgeries, for example in the use of local infiltration, spinal anesthesia, caudal anesthesia, or general anesthesia Among them, spinal anesthesia is commonly used for lower limb surgery which does not need a sophisticated machine and which has been performed for years before anesthetic equipment such as mechanical ventilators and monitoring devices was produced. The development of new local anesthetic agents, the use of opioids, and an interest in acute and chronic pain management have universalized spinal anesthesia. Immediate pain is very severe in lowerlimb surgery and difficul to control. Moreover, due to the short hospitalization period, there is a limit in the application of patient-controlled analgesia that permits patients to treat pain by directly activating doses of opoids .
Nalbuphine...
Nalbuphine is an agonist-antagonist opioid and provides prolonged duration of analgesia with
fewer side effects of fentanyl such as pruritus, nausea, and vomiting.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •male and female pt between 18 and 600 year
- •pt with lower limb surgeries with no. Indication for general anathesia
- •patient with no contraindication for spinal anatthesia
排除标准
- •pt who refuses
- •pt with hypersensivity to any drug
- •pt addicts opiods
- •chronic use of opiod
- •Inability to comprehend postoperatively the pain assessment scale/neuropsychiatric disorders.
研究组 & 干预措施
group F
patients will received intrathecal with dose 10-20ug
干预措施: fentanyl (Drug)
group N
Nalbuphine will given IV as shot in. Dose 1mg /kg
干预措施: Nalbuphine (Drug)
结局指标
主要结局
first request of rescue analgesia
时间窗: 24 hours
Duration of analgesia until first analgesic request
次要结局
未报告次要终点
研究者
Ahmed Khaled Helmy Abdelbasser
resident doctor at Anathesia and icu department Faculty of Medicine, Assiut University
Assiut University