Comparison of the Effects of Sugammadex and Neostigmine on Early Extubation, Intensive Care Unit Admission and Length of Stay, and Hospital Costs in Adult Cranial Surgery

Completed

• Conditions: Craniectomy; Sugammadex; Extubation; Recovery After Neuromuscular Block; Hospital Costs

• Registration Number: NCT06987357
• Lead Sponsor: Kanuni Sultan Suleyman Training and Research Hospital

Brief Summary

The aim of this study was to retrospectively investigate the effects of sugammadex or neostigmine, which are routinely used after the completion of surgery to antagonize (reverse) neuromuscular blockade in adult patients undergoing cranial surgery under general anesthesia, on early extubation in the operating room, intensive care unit admission and length of stay, length of hospital stay, and hospital costs.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-01
• Primary Completion: 2021-07-31
• Study Completion: 2021-07-31
• Status Verified: 2025-05
• Study First Submitted: 2025-05-09
• Study First Submitted QC: 2025-05-15
• Last Update Submitted: 2025-05-15
• Study First Posted: 2025-05-23
• Last Update Posted: 2025-05-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 112

Inclusion Criteria

• Patients from the American Society of Anesthesiology (ASA) I-II-III group,
• over the age of 18,
• who underwent elective surgery,
• underwent general anesthesia with sevoflurane anesthesia from volatile anesthetics,
• used rocuronium as a neuromuscular blocking agent

Exclusion Criteria

• Patients aged 18 and under,
• ASA IV and above,
• who underwent surgery under emergency conditions,
• who have incomplete follow-up form records and electronic media data,
• who were taken to the intensive care unit without neuromuscular blockade antagonism due to long surgery,
• who were treated with a neuromuscular blocking agent other than rocuronium,
• who were treated with a volatile anesthetic other than sevoflurane or with total intravenous anesthesia.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The amount of cost in the hospital process	through study completion, an average of 3 month
Length of stay in the intensive care unit	through study completion, an average of 3 month
Early extubation rate after two different neuromuscular blocking antagonist drugs	through study completion, an average of 3 month

Trial Locations

Locations (1)

Kanuni Sultan Suleyman Training and Research Hospital; 🇹🇷 İstanbul, Turkey