Efficacy and safety of iontophoresis in patients with age-related cataract
- Conditions
- Age-related cataractEye DiseasesSenile cataract
- Registration Number
- ISRCTN34571027
- Lead Sponsor
- Zhongshan Ophthalmic Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 118
1. ?Adults between the ages of 65 and 80 years old
2.? LOCS III nuclear opalescence score >=3.0 OR cortical cataract score >=3.0 OR posterior subcapsular score >=1.0 bilateral
3.? Able to commit to the 4-week follow up
4. ?Able to understand and sign an informed consent
1.? Types of cataracts other than age-related, including metabolic cataract, drugs and toxic cataract, congenital cataract, etc
2. ?Any other ocular pathology that may affect visual acuity, such as glaucoma, uveitis and retinopathy, etc
3.? Patients with inflammation of the ocular surface and the adjacent area
4.? History of ocular surgery or laser
5. ?Patients who are blind in one eye
6. ?Patients with uncontrolled systemic disease, i.e. high blood pressure (Bp > 160/100 mmHg), diabetes mellitus (GLU-AC >8mg/dl), kidney disease, etc
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Change of uncorrected visual acuity, measured by ETDRS chart at baseline, 1 week, 2 weeks, 3 weeks and 4 weeks<br> 2. Change of best-corrected visual acuity, measured by ETDRS chart at baseline, 1 week, 2 weeks, 3 weeks and 4 weeks<br> 3. LOCS III lens opacity grading, measured by slit-lamp examination at baseline, 2 weeks and 4 weeks<br>
- Secondary Outcome Measures
Name Time Method <br> 1.? Photographic evaluation of a change from baseline in nuclear, cortical, or posterior subcapsular cataract opacity grades, measured according to LOCSIII at baseline, 2 weeks and 4 weeks<br> 2. Lens density varies during 4 weeks follow-up measured by Pentacam at baseline, 2 weeks and 4 weeks<br> 3.? Adverse events within 4 weeks associated with iontophoresis and traditional Chinese medicine.<br> 4.? Visual satisfaction, measured by questionnaire at 4 weeks<br>