Hospital Management and 1-year Outcome of Patients Aged 70 Years and Older With Severe COVID-19
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 361
- 试验地点
- 4
- 主要终点
- Mortality of patients aged 70 years and over 1 year after diagnosis of SAR-COV2 infection
研究概览
简要总结
SARS-COV-2 infection can progress to acute respiratory distress syndrome and require hospitalization in the ICU in 5-20% of affected patients. Age is a major risk factor for developing a severe form and for death. ARDS related to SARS-COV-2 has specific features, including the need for long mechanical ventilation and length of stay and the use of corticosteroid therapy. These specificities are responsible for significant morbidity (neuromyopathy, delirium, post-resuscitation syndrome) and mortality during the first wave (46% at 3 months for the population of patients aged 70 years and over). To investigator's knowledge, no study has evaluated the prognosis in the ICU and the long-term functional outcome of elderly people admitted for a severe or critical form of COVID-19 since the major changes in management (dexamethasone, screening for thrombo-embolic complications, use of high-flow oxygen therapy as first-line treatment...).
Investigator therefore propose a 1-year follow-up of a cohort of patients aged 70 and over hospitalised in a conventional service or in intensive care for a severe or critical form of COVID-19. The objectives are to describe the prognosis and functional outcome of hospitalized elderly patients with severe COVID-19.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥ 70 years on admission to hospital
- •diagnosis of SARS-CoV-2 infection defined by a positive RT-PCR test
- •medical or critical care hospitalisation between 1 July 2020 and 31 August 2021
- •who experienced severe hypoxaemic acute respiratory failure defined as at least 4L/min of oxygen during hospitalisation
排除标准
- •Oxygen therapy < 4L/min during hospitalisation
- •Mc Cabe score 3 (chronic disease fatal at 1 year such as stage IV heart failure, ventilated respiratory failure, metastatic cancer, Child C cirrhosis)
- •dementia or cognitive disorders before hospitalisation reported in the medical record
- •patient GIR 1 to 4 before hospitalisation reported in the medical file or deduced from the description of the lifestyle
- •patient with an ADL score < 4 before hospitalisation reported in the medical record or deduced from the description of lifestyle
- •patient living in EHPAD before hospitalisation
- •non-French speaking patient
- •patient under guardianship or curatorship
- •refusal to participate in the study for patients surviving 1 year or refusal by a family member or trusted person
结局指标
主要结局
Mortality of patients aged 70 years and over 1 year after diagnosis of SAR-COV2 infection
时间窗: 6 months
The mortality was evaluated by the proportion of patients aged 70 years and over who died 1 year after diagnosis of SARS-CoV-2 infection who had severe acute respiratory failure defined by at least 4 L/min of oxygen therapy
Mortality of patients aged 70 years and over 1 year after diagnosis of SAR-COV2 infection
时间窗: 1 year after diagnosis of SarS-CoV-2
The mortality was evaluated by the proportion of patients aged 70 years and over who died 1 year after diagnosis of SARS-CoV-2 infection who had severe acute respiratory failure defined by at least 4 L/min of oxygen therapy
次要结局
- Overall hospital mortality among included patients(during hospitalization)
- In-hospital mortality among patients admitted to and not admitted to intensive care(end of hospitalization)
- Mortality 1 year after diagnosis of SARS-CoV-2 infection in patients who were discharged alive from hospital in the overall cohort and according to whether or not they were admitted to intensive care.(1 year after diagnosis of SarS-CoV-2)
- Outcome for patients admitted and discharged alive from hospital in terms of Quality of life(1 year after diagnosis of SarS-CoV-2)
- Outcome for patients admitted and discharged alive from hospital in terms of functionnal status(1 year after diagnosis of SarS-CoV-2)
- Hospital care for patients not admitted to intensive care(during hospitalization)
- Risk factors associated with 1-year outcomes in patients surviving hospitalization in the overall cohort and in the cohort of patients admitted to intensive care.(1 year after diagnosis SARS-CoV-2)