Prediction of Acute Kidney Injury in Patients With Sepsis Using Venous Excess Ultrasound Score
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intensive Care Unit
- Sponsor
- Mansoura University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Correlation between serial VEXUS score and AKI in patients with sepsis.
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis and septic shock are major healthcare problems, killing between one in three and one in six of those they affect. organ dysfunction can be represented by the Sequential Organ Failure Assessment (SOFA) score of 2 points or more (respiratory rate of 22/min or greater, altered mentation, or systolic blood pressure of 100 mm Hg or less), which is associated with an in- hospital mortality greater than 10%.
Septic shock is defined as a subset of sepsis in which profound circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone. Patients with septic shock can be clinically identified by a vasopressor requirement to maintain a mean arterial pressure of 65 mm Hg or greater and serum lactate level greater than 2 mmol/L (>18 mg/dL) in the absence of hypovolemia. This combination is associated with hospital mortality rates greater than 40%.
Detailed Description
All patients with two out of four of Systemic Inflammatory Response Syndrome (SIRS) criteria (heart rate greater than 90, respiratory rate greater than 20, temperature greater or equal to 38 ⁰ C or less than 36⁰ C, altered mental state) and suspected infection and one of the following risk factors ( Age greater than 65 years, Recent surgery Immunocompromised AIDS, chemotherapy, neutropenia, diabetes, renal failure, hepatic failure, cancer, alcoholism)should be considered at risk of sepsis according to emergency department sepsis guidelines 2022. The VExUS score ranges from Grades 0-3. In Grade 0, a non- dilated IVC (\< 2 cm) indicates that no congestion is present. In Grades 1- 3, the IVC diameter is \> 2 cm. In Grade 1, a dilated IVC and any combination of mildly abnormal flow patterns (but no severe features) indicates mild congestion. In Grade 2, a dilated IVC and one severely abnormal flow pattern indicates moderate congestion. In Grade 3, a dilated IVC and two or more severely abnormal flow patterns indicates severe congestion.
Investigators
Nevert Adel
assistant professor
Mansoura University
Eligibility Criteria
Inclusion Criteria
- •All patients with sepsis.
- •Patients aged between 21 and
- •Both sexes
Exclusion Criteria
- •Patients refused to participate in the study.
- •Renal failure.
- •Right ventricular dysfunction and dilatation.
- •Moderate to severe tricuspid regurge.
- •Cases of cirrhosis with liver cell failure.
- •Inadequate window.
- •IVC thrombus
Outcomes
Primary Outcomes
Correlation between serial VEXUS score and AKI in patients with sepsis.
Time Frame: 4 months
Correlation between serial VEXUS score and AKI in patients with sepsis.
Secondary Outcomes
- Assess correlation between VEXUS score and hemodynamics: mean arterial pressure, central venous pressure, vasopressor use, urine output and daily fluid balance and serum lactate.(4 months)