Alert Kidney Intervention
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Atlantic Health System
- Primary Endpoint
- number of participants who required dialysis
- Status
- Withdrawn
- Last Updated
- 4 years ago
Overview
Brief Summary
Acute kidney injury increases the risk for chronic kidney disease, length of stay, readmissions and mortality. Currently the only way to diagnose acute kidney injury is with a serum creatinine or drop in urine output. Biomarkers for acute kidney injury are well elevated before rise in creatinine. Hypothesis is that by implementing an electronic alert system with an algorithm followed by remote ischemic preconditioning will prevent acute kidney injury.
Detailed Description
The propose study is to incorporate an alert system in current medical health system and an algorithm will be used to activate clinicians and Nephrologist to confirm if patient is at high risk. Once identified as high risk the clinician and/or nephrologist will intervene and change current management if needed. First phase of study will look at an alert system and algorithm was enough to lower incidence of acute kidney injury. Phase 2 will also use alert system and algorithm that will be further randomized those that are identified as high risk for acute kidney injury to remote ischemic preconditioning.
Investigators
Shivangi K. Patel
Principal Investigator
Atlantic Health System
Eligibility Criteria
Inclusion Criteria
- •any admitted patients that are not excluded by exclusion criteria
- •Patients who's creatinine returns to baseline after admitted can be included in study if patient still remains admitted.
Exclusion Criteria
- •End stage renal disease
- •estimated glomerular filtration rate less then 20
- •Left ventricular assist device patients
- •observation status
- •hospice patients
- •pregnancy
- •age less then 18
- •acute kidney injury on admission defined as 1.5 times elevated creatinine prior to last admission's creatinine
- •nephrology consult already placed
- •renal transplant or nephrectomy within 1 year
Outcomes
Primary Outcomes
number of participants who required dialysis
Time Frame: during hospitalization, up to three months
need for initiation of dialysis after acute kidney injury develops during the admission
number of participants who developed acute kidney injury
Time Frame: during hospitalization, up to three months
development of acute kidney injury as measured by serum creatinine 1.5 times more then baseline
Secondary Outcomes
- number of participants who are placed on hospice or have expired(at time of admission when enrolled in study to 1 year post discharge)
- number of participants who are readmitted(discharged from when enrolled in study to 1 year post discharge)
- length of stay(during hospitalization, up to three months)
- progression to chronic kidney disease(at time of admission when enrolled in study to 1 year post discharge)
- number of participants who receive dialysis(at time of admission when enrolled in study to 1 year post discharge)