Master Athletic Laboratory Study ofIntramuscular Connective Tissue
Not Applicable
- Conditions
- healthy aging
- Registration Number
- DRKS00015764
- Lead Sponsor
- DLR - Institut für Luft- und RaumfahrtInstitut für Luft- und Raumfahrtmedizin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 46
Inclusion Criteria
• Regular running training (=4 hours per week) and participation in running competitions (athlete groups)
• Little or no physical activity, as defined by exercise-related energy expenditure of = 2 metabolic units per week (sedentary groups)
• Age between 20 and 35 (young groups)
• Age between 60 and 75 (old groups)
• Male
• Body mass index = 25 kg/m²
• Ability to consent
• Agreement and signed informed consent before the study
Exclusion Criteria
• Injuries or disorders that interfere with calf muscle contractions or with vertical jump testing
• Contraindications against magnetic resonance scanning
• Contraindications against muscle biopsy
• Diabetes
• Any condition classed as unsuitable by the executive medical director
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Muscle’s endomysium content (soleus biopsy, histology)
- Secondary Outcome Measures
Name Time Method - Muscle’s collagen content (soleus biopsy, Western blot)<br>- Muscle’s advanced glycation end products (soleus biopsy, ELISA)<br>- Muscle’s collagen cross-linking (soleus biopsy, ELISA)<br>- Muscle’s perimysium content (ultrasound)<br>- Muscle fascicle dynamics, defined as change in pennation angle between 10% and 90% of maximum voluntary contraction (B-mode ultrasound & dynamometry)<br>- Muscle’s elastic modulus (shear wave sonography) at rest and during graded contraction up to maximum<br>