Training of intramuscular connective tissue in elderly
Not Applicable
- Conditions
- M62.5M62.9Muscle wasting and atrophy, not elsewhere classifiedDisorder of muscle, unspecified
- Registration Number
- DRKS00015750
- Lead Sponsor
- Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 56
Inclusion Criteria
Physical readiness to participate in planned resistance training
Exclusion Criteria
Coronary heart disease;
Severe pulmonary (> 55 mmHg) or systemic arterial hypertension (> 160/95 mmHg);
Acute disease or infection;
Musculoskeletal disorders (e.g., severe osteoarthritis of the knee);
Blood clotting disorders or taking of anticoagulant medicines or platelet aggregation inhibitors;
Malnutrition (Mini Nutritional Assessment);
Any contraindication for MRI;
Hormone replacement therapy;
Regular strength training within 6 months prior to inclusion;
Moderate to severe peripheral artery disease;
Severe varicosis
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Isometric and isokinetic muscle strength of knee extensor and ankle plantarflexor muscles
- Secondary Outcome Measures
Name Time Method Functional performance measures (timed sit-to-stand, handgrip strength, 6-min walk test);<br>Muscle volumes, architecture and echogenicity;<br>Gene expression and network proteins of intramuscular connective tissue (muscle biopsies);<br>Muscle fiber types;<br>Neural activation capacity