StudY of effect of Nimodipine and Acetaminophen on Postictal Symptoms after ECT
Phase 2
Recruiting
- Conditions
- Postictal symptoms1003991110027946
- Registration Number
- NL-OMON48237
- Lead Sponsor
- Rijnstate Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 33
Inclusion Criteria
Adulthood (age > 17 years);
Current clinical diagnosis of depressive episode (unipolar, bipolar,
schizoaffective);
Willingness and ability to give written informed consent and willingness and
ability to understand, to participate and to comply with the study
requirements.
Exclusion Criteria
Known adverse reactions to acetaminophen or nimodipine. In that case
participants can still be included into the other intervention groups;
Chronic use of acetaminophen, calcium-antagonists or NSAID*s that cannot be
interrupted for less than two days before the ECT-session.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome measure will be *time to EEG normalization*, defined as the<br /><br>time interval between seizure onset and return to the pre-ECT (baseline) EEG,<br /><br>quantified with the temporal Brain Symmetry Index.</p><br>
- Secondary Outcome Measures
Name Time Method