Comparison of the effect of Acetaminophen and Ibuprofen in pain relief following Adenotonsillectomy.
Phase 3
- Conditions
- Adenotonsillectomy.Enlargement of tonsils, Enlargement of adenoidsJ35.1,J35.
- Registration Number
- IRCT2013071814047N1
- Lead Sponsor
- Vice chancellor for research, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1-No Allergy to Non Steroid Anti-Inflammatory Drugs
2-No History of coagulopathy
3-No Renal and Hepatic disorder
4-No Severe Asthma (recently admission or treatment with oral corticosteroid)
5-No Family history of coagulopathy
6-No Evidence of Mental retardation
Exclusion Criteria
1- Severe and uncontrollable bleeding during and after surgery
2- Severe pain after surgery which needs additional analgesic
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain score. Timepoint: Six hours postoperative, at the end of first postoperative day, at the end of second postoperative day. Method of measurement: with visual analogue pain scale (1-10 score).
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie acetaminophen and ibuprofen efficacy in post-adenotonsillectomy pain for 4-10 year old children?
How do acetaminophen and ibuprofen compare to standard-of-care analgesics in managing post-adenotonsillectomy pain in pediatric patients with J35.1/J35.0 conditions?
Which biomarkers predict differential response to acetaminophen versus ibuprofen in children undergoing adenotonsillectomy for tonsillar/adenoidal hypertrophy?
What adverse events are associated with acetaminophen and ibuprofen in IRCT2013071814047N1, and what management strategies are recommended?
Are there alternative analgesics or combination therapies that outperform acetaminophen and ibuprofen for post-adenotonsillectomy pain in 4-10 year olds?