The Relationship Between Cognitive Function and Functional Capacity, Cognitive Reserve, Reaction Time in Patients With Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 76
- 试验地点
- 1
- 主要终点
- Cognitive Reserve Index Questionnaire
研究概览
简要总结
The aim of the study is to investigate the relationship between cognitive function, functional capacity, cognitive reserve and reaction time in patients with multiple sclerosis.
详细描述
Cognitive impairment in patients with MS is a common problem that significantly affects quality of life. It shows an association between functional capacity and physical fitness levels and cognition in non-MS populations, and especially in the elderly.
Although cognitive dysfunctions are known, few studies have been found on its relationship with secondary problems caused by the disease and its correlation with other symptoms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Relapsing-remitting MS diagnosis
- •Expanded Disability Status Scale score <5.5
- •Being able to use a smart phone
- •No relapse during the last 30 days
- •Being between the ages of 18-65
- •Mini-Mental State Examination score>24
排除标准
- •Severe Visual Impairment
- •Severe Psychiatric Disorder,
- •Severe Arthritis in Knee or Hip,
- •Pregnancy and other neurological or vestibular disorders that may prevent the patient from completing the functional examination
研究组 & 干预措施
Patient group
Patients with a definite diagnosis of MS according to McDonald diagnostic criteria
干预措施: Cognitive function, cognitive reserve, functional capacity, reaction time, strength, fatigue, depression and general health assessment (Other)
Control Group
Healthy individuals
结局指标
主要结局
Cognitive Reserve Index Questionnaire
时间窗: Baseline
A tool used to quantify, in a standardized model, cognitive reserve through an interview to the participant or to the caregiver. The questionnaire collects demographic information regarding the school curriculum, work and type of free-time activities. These three different indices (CRI-School, CRI-Work and CRI-Free Time) are then combined into a single "Index of Cognitive Reserve".
Functional capacity assessment
时间窗: baseline
The STS-5 test, on the other hand, requires patients to perform five sit-stand cycles in a standard chair (0.43-m high and 0.45-m wide) as quickly as possible, measured in seconds, and is used as an indicator of lower extremity muscle strength.
Cognitive function
时间窗: Baseline
A mobile application called Trail Making Test was used to evaluate visual attention and cognitive flexibility. The completion time of subsections A and B was recorded. Working memory will be evaluated using a mobile application called Digit Span test. This application gives your maximum digit memory. This score has been saved.
Visiospatial perception
时间窗: Baseline
The visuospatial perception was evaluated with the help of the mobile application called Corsi Block Tapping test. The highest span in this application is recorded.
Functional capacity assessment
时间窗: Baseline
6-minute walk test were used. The 6-minute walk test requires patients to cover as much distance as possible in a six-minute period. The walking distance is recorded.
次要结局
- Fatigue Severity Scale.(Baseline)
- Nottingham Health Profile.(Baseline)
- Beck Depression Inventory(Baseline)
- Hand grip strength(Baseline)
- Reaction time(Baseline)
研究者
Burcu Talu
Associate professor
Inonu University