Effect of Low Level Diode Laser Biostimulation on Implant Stability

Not Applicable

Completed

• Conditions: Immediate Implant Placement; Laser; Biostimulation

• Registration Number: NCT07044245
• Lead Sponsor: Alexandria University

Brief Summary

Tooth loss is accompanied by bone loss in all dimensions, so preservation of the bone is mandatory for placement of dental implant, as bone quantity and quality are predictive factors in achieving proper primary stability. Low level bio stimulation has stimulatory effect on bone cells so it can be used in immediate implants to increase bone formation around the implant.

the Aim of this study is to evaluate the effect of low-level diode laser Biostimulation on immediate implants in maxillary premolars.

Detailed Description

20 patients with unrestorable maxillary premolars were included in the study treated with immediate implants. Patients were divided into two groups (n=10). Group 1 Received immediate implant with low level diode laser application (study), and group 2 received immediate implant without laser application (control). Preoperative clinical and radiographic evaluation, immediate post operative and after 4 months radiographic evaluation to assess stability and bone density around the implant.

Study Timeline

• Study Start: 2023-11-01
• Primary Completion: 2024-08-01
• Study Completion: 2025-03-01
• Status Verified: 2025-06
• Study First Submitted: 2025-06-19
• Study First Submitted QC: 2025-06-27
• Last Update Submitted: 2025-06-27
• Study First Posted: 2025-06-29
• Last Update Posted: 2025-06-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Patients with unrestorable maxillary premolars with sufficient bone quantity to receive the dental implant.
2. Age ranging from 25-45.
3. Patients with no local or systemic pathology that can interfere with normal wound healing.
4. Non- smokers.
5. Patients that are properly motivated to complete follow up visits.
6. Patients with adequate oral hygiene or willing to improve their oral hygiene to ensure uncompromised wound healing.

Exclusion Criteria

1. Patients with uncontrolled medical condition that can affect surgical outcome or bone and wound healing. (ex: diabetes mellitus)
2. Patients with periapical pathology that may contraindicate immediate implant placement.
3. History of receiving irradiation in head and neck region

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Implant Stability Assessment using Radio frequency analysis	4 month	Secondary implant stability analysis was performed 4-months after implant placement. Radio frequency analysis (RFA) was performed using Osstell device (Integration diagnostic Ltd. Company, Sävedalen, Sweden). Primary and secondary implant stability were analyzed and compared. The use of the Osstell and ISQ values were obtained by a blinded operator

Secondary Outcome Measures

Name	Time	Method
Radiographic assessment of the management of the crestal bone width and changes in labial bone thickness.	4 months	A postoperative CBCT will be taken within 24 hours of implant placement followed by a 6-months scan, and values will be compared with the preoperative record. The assessment will be conducted using the tools on the "On Demand 3D App." Software\*. The following criteria will be assessed:

Trial Locations

Locations (1)

Faculty of Dentistry, Alexandria University; 🇪🇬 Alexandria, Egypt