Pain reduction efficacy of intra-articular platelet-rich plasma injection in comparison with intra-articular corticosteroid injection in knee osteoarthritis with delayed joint replacement, randomized controlled trial
Phase 4
Recruiting
- Conditions
- End-stage osteoarthritis of knee with delayed joint replacement surgery related with increased pain and impaired activity function. PRP and Steroid Injection could reduced pain and improved function.Advance Stage OA Knee, Delayed Surgery, PRP Injection, Steroid Injection
- Registration Number
- TCTR20220801003
- Lead Sponsor
- avamindradhiraj University Research Fund
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
1.Primary OA knee KL III-IV
2.Age 55 to 80 years
3.TKA Waiting List > 6 months
Exclusion Criteria
Allergy to drug in study
Previous interventions on the knee joint
Impair Renal Function (GFR < 30 ml/min)
Chronic pain not related to knee joint
Blood clotting disorders or treated with anticoagulants
Uncontrolled diabetes (Hb A1C in last 3 months >= 8%)
Hb < 12 mg/dl or Platelet < 150,000
Local wound infection at injection site
Autoimmune diseases
Pregnancy or Breastfeeding
Chronic Liver Disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain Score 2 weeks, 6 weeks, 12 weeks, 24 weeks NRS
- Secondary Outcome Measures
Name Time Method Functional Outcome 2 weeks, 6 weeks, 12 weeks, 24 weeks WOMAC,Complication 2 weeks, 6 weeks, 12 weeks, 24 weeks Incidence