To know the use of biomarkers and ultrasound to predict multi-organ dysfunction syndrome and death in mechanically ventilated Acute Respiratory Distress Syndrome patients.

Not Applicable

• Conditions: Health Condition 1: J981- Pulmonary collapse

• Registration Number: CTRI/2023/05/052937
• Lead Sponsor: Dr. Souvik Chaudhuri

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Patients with ARDS as per Berlin definition of ARDS (acute in onset, meaning onset over 1 week or less, bilateral opacities must be present and may be detected on chest radiograph, PaO2/FiO2 ratio <300mmHg with a minimum of 5 cmH20 Positive End-Expiratory Pressure

{PEEP}, and must not be fully explained by cardiac failure or fluid overload).

2. Patients aged 18-90 years of age.

3. Patients with ARDS who are intubated and are on invasive mechanical ventilation.

Exclusion Criteria

1. More than 24 hours elapsed since admission to ICU with ARDS.

2. ARDS patients on - corticosteroid and tocilizumab, sarilumab, disease-modifying anti- rheumatoid drugs (which can alter levels of inflammatory mediators).

3. Patients with hematological malignancies (altered lymphocyte, neutrophil counts)

4. Patients diagnosed with cardiogenic pulmonary oedema (which can alter the lung ultrasound findings).

5. Patients not expected to survive the next 24-48 hours with the SOFA score on ARDS diagnosis being >= 22.

6. Non-invasive Ventilator (NIV) ARDS patients.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Early MODS (SOFA Score increase â?¥ 2 from Day 1 to Day 3). <br/ ><br>2. Mortality. <br/ ><br>3. Days of ventilation. <br/ ><br>4. Days of ICU stay. <br/ ><br>5. Simple, difficult, and prolonged weaning. <br/ ><br>6. Readmission to ICU within 48 hours. <br/ ><br>Timepoint: 1. Early MODS (SOFA Score increase â?¥ 2 from Day 1 to Day 3). <br/ ><br>2. Mortality. <br/ ><br>3. Days of ventilation. <br/ ><br>4. Days of ICU stay. <br/ ><br>5. Simple, difficult, and prolonged weaning. <br/ ><br>6. Readmission to ICU within 48 hours. <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
1. Readmission to ICU within 48 hours.Timepoint: 1. Readmission to ICU within 48 hours.