Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery

Phase 4

Completed

• Conditions: Heart Valve Diseases
• Interventions: Procedure: remote ischemic pre and postconditioning (RIPC)

• Registration Number: NCT01427621
• Lead Sponsor: Yonsei University

Brief Summary

Pulmonary dysfunction after cardiac surgery with CPB remains to be a problem complicating the postoperative course of the patients. The investigators hypothesized that RIPCcom, combined intervention of remote ischemic preconditioning and remote ischemic postconditioning, would confer beneficial influence on inflammatory response and resultant postoperative pulmonary dysfunction after CPB in patients undergoing complex valvular heart surgery who are at increased risk of postoperative pulmonary dysfunction.The aim of this study was to evaluate the lung-protective effect of combined remote ischemic pre- and post-conditioning in patients undergoing complex valvular heart surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-03
• Primary Completion: 2010-11
• Study Completion: 2011-05
• Status Verified: 2011-08
• Study First Submitted: 2011-08-30
• Study First Submitted QC: 2011-08-31
• Last Update Submitted: 2011-08-31
• Study First Posted: 2011-09-01
• Last Update Posted: 2011-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• patients undergoing valvular heart surgery.
• Age: 20~80.

Exclusion Criteria

• Emergency operation.
• patients with peripheral vascular disease.
• Patients with a known history or clinical evidence of chronic obstructive pulmonary disease.
• Patients with hepatic or renal dysfunction
• Patients with acute myocardial infarction within 1 week before surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
RIPCcom group	remote ischemic pre and postconditioning (RIPC)	-

Primary Outcome Measures

Name	Time	Method
Comparison of postoperative PaO2/FiO2	at 10 minutes after anesthetic induction	Comparison of postoperative PaO2/FiO2 between RIPCcom group and Control group.