Comparing the Analgesic Effect of Two Different Doses of Dexmedetomidine Added to Bupivacaine in Ultrasound-guided Transversus Abdominis Plane Block in Patients Undergoing Lower Abdominal Cancer Surgeries; A Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Total morphine consumption during the first 24 hours postoperatively
研究概览
简要总结
The aim of this study to determine the optimal dose of dexmedetomidine as an adjuvant to bupivacaine in U.S guided TAP block for preemptive analgesia In patients undergoing lower abdominal cancer surgeries.
详细描述
The transversus abdominis plane (TAP) involves innervations of the anterolateral abdominal wall derived from T6-L1. The block can be given either by anatomical landmark technique or by using an ultrasound probe. The local anesthetic is deposited in a plane between internal oblique and transversus abdominis muscle. It provides adequate postoperative analgesia following various abdominal surgeries.Dexmedetomidine is an alpha-2 agonist that has been approved as a venous sedative and an adjuvant for pain relief .In previous studies, the addition of dexmedetomidine to bupivacaine in the TAP block has prolonged the effect of this block . So far, the optimal dose of dexmedetomidine for the TAP block has not been determined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age from 18 to 65 years old
- •lower abdominal cancer surgery
排除标准
- •patient refusal
- •the local anesthetic allergy
- •coagulopathy
- •local infection at the procedure site
- •psychic patients
- •patient on chronic opioid use
研究组 & 干预措施
tap block with 0.5 μg/kg dexmedetomidine
will receive pre-emptive ultrasound-guided tap block with 0.5 μg/kg dexmedetomidine in 20 ml volume added to 20 mL of 0.25% bupivacaine (40 ml in total) 20 ml will be applied on each side of the abdominal wall after induction of GA.
干预措施: Dexmedetomidine as adjuvent to bupvacaine in tap block (Drug)
tap block with 1.5 μg/kg dexmedetomidine
will receive pre-emptive ultrasound-guided tap block with 1.5 μg/kg dexmedetomidine in 20 ml volume added to 20 mL of 0.25% bupivacaine (40 ml in total) 20 ml will be applied on each side of the abdominal wall after induction of GA.
干预措施: Dexmedetomidine as adjuvent to bupvacaine in tap block (Drug)
结局指标
主要结局
Total morphine consumption during the first 24 hours postoperatively
时间窗: First 24 hours postoperative
Morphine consumption during the First 24 hours postoperative
次要结局
- Severity of pain using Visual analogue scale(First 24 hours postoperative)
- Patient level of sedation using four point modified ramsy scale(First 24 hours postoperative)
研究者
Kerolos Salama Tawfeek
Resident
Assiut University