The Effect of Repeated Dose of Decapeptile on Fertility Rate in PCOS

Phase 3

• Conditions: Infertility.; Female infertility associated with anovulation; N97.0

• Registration Number: IRCT20180708040381N5
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 27 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

Selection of women with PCOS based on ESHRE ASRM Rotterdam criteria
Stimulation with GnRH antagonist protocol
Age 20-38 years
E2 concentration > 2500 international units on the trigger day
Body mass index > 18 and < 30
Having an indication for IVF or ICSI
Willingness to participate in the study

Exclusion Criteria

severe cause of male infertility
Uterine anomalies
Severe endometriosis
metabolic disease (e.g. metabolic syndrome)
Patients with hypogonadism, hypogonadotropism
Patients with underlying diseases such as thyroid disease, hyperprolactinemia, Cushing's syndrome, ovarian and adrenal tumors, diabetes, etc.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
umber of mature oocyte. Timepoint: 34-36 hours after decapeptil injection. Method of measurement: Transvaginal ultrasound.;Number of retrieved oocytes. Timepoint: 34-36 hours after decapeptil injection. Method of measurement: Transvaginal ultrasound.;The number of blastocysts. Timepoint: Two weeks after administration of Decapeptil. Method of measurement: Abdominal ultrasound.

Secondary Outcome Measures

Name	Time	Method
Positive pregnancy test. Timepoint: 4 weeks after IVF. Method of measurement: Beta HCG test.