Comparison of D2 vs D3 Lymph Node Dissection for Right Colon Cancer (RICON)

Not Applicable

Active, not recruiting

• Conditions: Colon Cancer
• Interventions: Procedure: Right Hemicolectomy with D3 lymph node dissection; Procedure: Right Hemicolectomy with D2 lymph node dissection

• Registration Number: NCT03200834
• Lead Sponsor: G.V. Bondar Republican Cancer Center

Brief Summary

Comparing different method of surgical technique D2 lymph node dissection vs D3 for right colon cancer.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-25
• Study First Submitted: 2017-03-25
• Study First Submitted QC: 2017-06-26
• Study First Posted: 2017-06-27
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-23
• Last Update Posted: 2025-03-26
• Primary Completion: 2029-01-03
• Study Completion: 2029-01-03

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 239

Inclusion Criteria

1. Agreement of the patient to participate in trial
2. Colon cancer (only adenocarcinoma )
3. The tumor located between the cecum and the right 1/3 of transverse colon
4. Tumors T3,Т4а,b N0-2 (II-III stages)
5. Tolerance of chemotherapy
6. ECOG 0-2

Exclusion Criteria

1. Patients with distant metastases
2. Tumors T1-2 (I stage)
3. Complications of tumor (perforation and full bowel obstruction)
4. Previous radiotherapy or chemotherapy
5. Synchronous or metachronous tumors
6. Women during Pregnancy or breast feeding period

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
D3 lymph node dissection for right colon cancer	Right Hemicolectomy with D3 lymph node dissection	Hemicolectomy for right colon cancer with D3 lymph node dissection
D2 lymph node dissection for right colon cancer	Right Hemicolectomy with D2 lymph node dissection	Hemicolectomy for right colon cancer with D2 lymph node dissection

Primary Outcome Measures

Name	Time	Method
5-year survival	Up to 5 years post-operative	death from any cause

Secondary Outcome Measures

Name	Time	Method
morbidity	within the first 30 days after surgery	postoperative complications
mortality	within the first 30 days after surgery	death after surgery
Disease free survival 5 years after initial surgery	Up to 5 years post-operative	local and distant metastasis during 5 years after operation

Trial Locations

Locations (1)

G.V. Bondar Republican Cancer Center; 🇺🇦 Donetsk, Ukraine