Cream Containing Sericin and Turmeric in Psoriasis Patients

Not Applicable

Not yet recruiting

• Conditions: Psoriasis
• Interventions: Drug: Sericin extract and turmeric extract cream; Drug: Triamcinolone acetonide 1% Cream

• Registration Number: NCT06482398
• Lead Sponsor: Chulalongkorn University

Brief Summary

Psoriasis lesion is divided into two parts. Half of the lesion will apply cream containing sericin and turmeric and another will apply steroid cream (control). The samples will be apply two times a day for 8 weeks. Psoriasis area and severity index, physician global assessment, body surface area of lesion, dermatology life quality index, Itching score, adverse reaction are evaluated before, after using the samples for 4 and 8 weeks.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-06
• Study First Submitted: 2024-06-21
• Study First Submitted QC: 2024-06-28
• Last Update Submitted: 2024-06-28
• Study Start: 2024-07-01
• Study First Posted: 2024-07-01
• Last Update Posted: 2024-07-01
• Primary Completion: 2025-06-30
• Study Completion: 2025-07-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age over 18 years
• Patients with body surface area of psoriasis lesion less than 10, have psoriasis area and severity index less than 10 , and no lesion at face, hands,feet, and genital area
• No topical application on psoriasis lesion at least 2 weeks
• Willing to attend the study

Exclusion Criteria

• Uncontrolled diseases
• Allergic to sericin turmeric and steroid
• Other skin diseases
• Pregnancy and lactation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sericin extract and turmeric extract cream	Sericin extract and turmeric extract cream	Apply the sample 2 times a day for 8 weeks
Triamcinolone acetonide 1% cream	Triamcinolone acetonide 1% Cream	Apply the sample 2 times a day for 8 weeks

Primary Outcome Measures

Name	Time	Method
Psoriasis Area and Severity Index	8 weeks	Physician will evaluate the psoriasis lesion using Psoriasis Area and Severity Index. The score is graded 0 to 72 (low score means less severity and high score means high severity).

Secondary Outcome Measures

Name	Time	Method
Physician Global Assessment	8 weeks	Physician will evaluate the psoriasis lesion using Physician Global Assessment score (0 to 6, 0 means completely cleared, except for possible residual nonerythematous discoloration and 6 means condition worsened).
Itching score	8 weeks	Patients will assess itching score using visual analogue scale (0 to 10, 0 means low severity and 10 means high severity).
Body surface area of lesion	8 weeks	Physician will evaluate body surface area of psoriasis lesion in percentage. (low percentage means the lesion area decrease and high percentage means the lesion area increase).
Dermatology Life Quality Index	8 weeks	Patients will assess dermatology life quality score (0 to 30, 0 means high life quality and 30 means low life quality).