A Feasibility Study of Training in a Local Community Aimed Upon Health Promotion With Special Emphasis on Musculoskeletal Health Effects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 2
- 主要终点
- Whole-body and regional BMD
研究概览
简要总结
To minimize fracture risk, diverse and varied training of high intensity (multimodal training) is recommended to increase bone strength. However, the effectiveness of different training programmes performed in community settings remain uncertain. The present study aimed to evaluate the feasibility and the effectiveness of 19-week of multimodal training in a local community center in Copenhagen, Denmark. The health promotion initiative had special emphasis on musculoskeletal health in postmenopausal women.
详细描述
A local community center was offering supervised multimodal training (MMT) to postmenopausal, healthy women twice weekly, and the aim of the present study was to evaluate the feasibility and the musculoskeletal health promoting effects of the training. The evaluation study lasted for 19 weeks, and the average attendance rate of MMT participants had to be > 1 hour weekly. The primary outcomes were bone mineral density (BMD) assessed by Dual-Energy X-ray Absorptiometry (DXA) scanning and the fasted plasma concentration of bone turnover markers (BTM): N-terminal propeptide of type I procollagen (P1NP) , C-terminal telopeptide of type I collagen (CTX), Osteocalcin), while secondary outcomes were body composition variables, dynamic postural balance and functional muscle strength. To test within- and between-group differences in the pre and post outcomes the training group (MMT) was compared with a sedentary control group (CON).
Every participant was fully informed before giving her written informed consent to the procedures and potential discomfort associated with the study. The study was conducted in accordance with the Declaration of Helsinki and approved by the local ethics committee of the Capital Region of Denmark, H-18044190.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- — 至 70 Years(Child, Adult, Older Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •past menopause
- •non-smoking
- •BMI <30 kg/m2
排除标准
- •T-score < -3 SD in the lumbar spine or hip
- •Z-score > 1.5 SD)
- •use of hormone therapy, medical treatment or supplements that affect bone metabolism
- •previous or current medical condition affecting bone health
- •engagement in regular and systemic weight-bearing training or strength training during the preceding two years
结局指标
主要结局
Whole-body and regional BMD
时间窗: 19 weeks
bone mineral density (g/cm2)
Osteocalcin
时间窗: 3 weeks and 19 weeks
Concentration of Osteocalcin in plasma in fasted state (µg/l)
P1NP
时间窗: 3 weeks and 19 weeks
Concentration of P1NP in plasma in fasted state (µg/l)
CTX
时间窗: 3 weeks and 19 weeks
Concentration of CTX in plasma in fasted state (ng/l)
次要结局
- Body weight(19 weeks)
- Body fat percentage(19 weeks)
- Visceral adipose tissue (VAT)(19 weeks)
- BMI(19 weeks)
- Total fat mass(19 weeks)
- dynamic balance(19 weeks)
- Total lean body mass (LBM)(19 weeks)
- Whole-body bone mineral content (BMC)(19 weeks)
- dynamic muscle strength(19 weeks)
研究者
Ewa Wulff Helge
Associate Professor, Ph.D.
University of Copenhagen
