Comparison of Pesticide and Pharmaceutical Contaminants Levels in Placenta and Cord Blood Samples of Pregnant Women With Fetal Growth Retardation and Healthy Pregnant Women

• Conditions: Fetal Growth Retardation
• Interventions: Other: . Pesticide and Pharmaceutical analysis

• Registration Number: NCT05088148
• Lead Sponsor: Kutahya Health Sciences University

Brief Summary

Aim: In this study, pesticide and pharmaceutical contaminants levels in the placenta and cord blood of pregnant women with fetal growth retardation and healthy pregnant women will be compared in placenta and cord blood samples after delivery.

Detailed Description

The study will be conducted with a total of 40 pregnant women, 20 of whom are in the control groups and those with FGR diagnoses. Cases in both groups will be matched in terms of demographic information. Demographic information (including socioeconomic status, educational level, region of residence), ultrasound and Doppler examination results, newborn weight at birth, APGAR score, gender, mode of delivery, whether there is a need for neonatal intensive care or not will be recorded.

Study Timeline

• Status Verified: 2021-10
• Study First Submitted: 2021-10-11
• Study First Submitted QC: 2021-10-11
• Study First Posted: 2021-10-21
• Study Start: 2022-03-29
• Last Update Submitted: 2022-03-31
• Last Update Posted: 2022-04-01
• Primary Completion: 2023-02-26
• Study Completion: 2023-03-26

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

• Between the ages of 18-40 years
• Gestational age between 320/7 - 396/7 weeks
• Singleton pregnancy
• For the FGR group: estimated fetal weight <10th percentile
• For the control group: being healthy pregnant
• Intact amniotic membrane

Exclusion Criteria

• Multiple pregnancies
• Cardiovascular disease
• Chronic hypertension
• Autoimmune disease
• Intrahepatic cholestasis of pregnancy
• Preeclampsia-eclampsia
• Sepsis
• Placenta accreta spectrum
• Abnormalities of placenta
• The chromosomal or congenital structural anomaly of the fetus
• Smoking
• BMI >30 kg/m2

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group 1: FGR group	. Pesticide and Pharmaceutical analysis	Estimated fetal weight \<10th percentile
Group 2: Control group	. Pesticide and Pharmaceutical analysis	Healthy pregnants who will give birth 37th and after gestational week

Primary Outcome Measures

Name	Time	Method
Pesticide and Pharmaceutical analysis	1 year	Pesticide and pharmaceutical contaminants levels in pregnant women's placenta and cord blood will be measured in placenta and cord blood samples after delivery.

Secondary Outcome Measures

Name	Time	Method
Multi logistic regression analysis.	1 month	If there is a significant difference in other data, including the pesticide and pharmaceutical contaminants levels, in the FGR group, the effect of each factor on the development of FGR will be analyzed by multi logistic regression analysis.
ROC analysis	1 month	If the pesticide and pharmaceutical contaminants levels is found to be significantly higher in the FGR group, the cut-off value will be obtained by ROC analysis.