Using Abdominal expiratory muscle thickness to estimate successful withdrawal of mechanical ventilation in critically ill patients

Not yet recruiting

Conditions: Illness, unspecified,

Registration Number: CTRI/2022/04/041810

Brief Summary: Weaning is the process of withdrawing mechanical ventilator support and transferring the work of breathing from ventilator to the patient. Failure of weaning from mechanical ventilation is a common problem faced in ICU, and several methods have been developed to predict weaning failure. The abdominal wall muscles are critical for protective reflexes such as coughing and thus may affect weaning in patients on mechanical ventilator. The aim of our study is to evaluate the thickness of abdominal expiratory muscles as a predictor of successful weaning in ready to wean critically ill patients on mechanical ventilation.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 50

Inclusion Criteria

1)Age>18 years.
2)Requiring invasive mechanical ventilation at ICU admission.
3)Expected duration of mechanical ventilation >72 hours.
4)Ready to undergo spontaneous breathing trial.

Exclusion Criteria

Past history of neuromuscular disorders Mechanical ventilation>48 hrs within current hospital admission Obesity (BMI>35) Pregnant women Abdominal wound at proposed location of ultrasound probe due to recent abdominal surgery.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Abdominal expiratory muscle thickness as a predictor of successful weaning in ready to wean critically ill patients receiving mechanical ventilation.	At admission \| At 72 hours \| Just before Spontaneous breathing trial in ready to wean patients

Secondary Outcome Measures

Name	Time	Method
Correlation between change in expiratory muscle and diaphragmatic thickness in critically ill patients receiving mechanical ventilation.	At admission
Factors predicting change in abdominal expiratory muscle thickness in critically ill mechanically ventilated patients.	During ICU stay
To assess time dependent changes of expiratory muscle thickness in critically ill mechanically ventilated patients	At admission

Trial Locations

Locations (1): All India institute of medical sciences, RISHIKESH
🇮🇳
Dehradun, UTTARANCHAL, India
All India institute of medical sciences, RISHIKESH
🇮🇳Dehradun, UTTARANCHAL, India
POOJA C S
Principal investigator
9110686619
poojaiyengar007@gmail.com