Partial neuromuscular blockade to facilitate lung and diaphragm protective mechanical ventilation in ICU patients: A randomized controlled pilot study.
Phase 4
Recruiting
- Conditions
- Middenrif / longfunctieDiaphragm dysfunctionlung injury due to mechanical ventilation
- Registration Number
- NL-OMON50261
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
- high respiratory drive, defined as tidal volume > 8ml/kg PBW on inspiratory
support of 12cmH2O.
- sedation level: RASS <= -3
- ventilated in pressure support mode
Exclusion Criteria
- recent use of NMBA (<2 hrs)
- arterial pH <7.25
- hemodynamic instability, i.e. high dose vasopressors (>0.5 µg/kg/min) or
inotropes (dobutamine >15 µg/kg/min or enoximone >25 µg/kg/min)
- intracranial pressure >20 cmH2O
- past medical history of neuromuscular disorders
- pregnancy
- known previous anaphylactic reaction to NMBA*s.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method