Influence of High Vitamin C Dose on Lactate During and After Extracorporeal Circulation

Not Applicable

Completed

• Conditions: Bypass Complication; Cardiac Disease; Valve Disease, Heart; Vitamin C; Hyperlactatemia

• Registration Number: NCT04046861
• Lead Sponsor: University Medical Centre Maribor

Brief Summary

The aim of our study is to find out whether high doses of vitamin C before cardiopulmonary bypass and during the first 24 hours after that have and impact of lowering the incidence of hyperlactatemia.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-07-27
• Study First Submitted QC: 2019-08-03
• Study First Posted: 2019-08-06
• Study Start: 2023-03-01
• Primary Completion: 2023-12-01
• Study Completion: 2024-09-01
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-19
• Last Update Posted: 2025-02-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• > 18 years old patients with cardiac disease needing surgery (coronary bypass, valve replacement)

Exclusion Criteria

• dementia
• kidney stones
• dialysis
• haemochromatosis
• thalassemias
• G-6-P deficiency

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Concentration of lactate	up to 30 hours	Measuring the concentration of lactate before cardiopulmonary bypass, after aortic clamp removal, at ICU admission,then every 6 hours

Secondary Outcome Measures

Name	Time	Method
dose of noradrenaline and other vasopressors	up to 36 hours	The need for noradrenaline and other vasopressors (e.g. vasopresin) during the surgery and in the 24-hours after the end of the surgery

Trial Locations

Locations (1)

Department od anesthesiology, intensive care and pain management; 🇸🇮 Maribor, Slovenia