To construct an early dynamic change model of HBV-RNA to guide the clinical cure of chronic hepatitis B with a short course of PegIFNa-2b
Not Applicable
Recruiting
- Conditions
- Chronic Hepatitis B
- Registration Number
- ChiCTR2400088982
- Lead Sponsor
- West China Hospital of Sichuan University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- HBsAg and HBeAg positive;<br>2. All patients had not used interferon antiviral therapy before enrollment.<br>3. The diagnosis met the diagnostic criteria of the 2022 revised Guidelines for the prevention and treatment of chronic hepatitis B.<br>4. Voluntarily cooperate to complete the follow-up.<br>
Exclusion Criteria
- Pregnancy or planned pregnancy in the near future;<br>2. Underlying diseases such as psychiatric history (schizophrenia or severe depression), uncontrolled epilepsy, unabstinent alcohol/drug addict, uncontrolled autoimmune disease, decompensated liver cirrhosis, thyroid disease, severe infection, retinal disease, heart failure, chronic obstructive pneumonia, etc.<br>3. Neutrophil count < 1.0×10^9/L and platelet count < 50×10^9/L before treatment.
Study & Design
- Study Type
- Observational study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum HBV RNA load (Absolute decrease; clearance rate; seroconversion rate);Serum HBcrAg load (Absolute decrease; clearance rate; seroconversion rate);Serum HBsAg levels (Absolute decrease; clearance rate; seroconversion rate);
- Secondary Outcome Measures
Name Time Method Serum ALT levels;