Influence of Air Quality on the Development and Progression of Premature Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 4,272
- 试验地点
- 1
- 主要终点
- To evaluate the impact of environmental pollutants on the incidence of the combined variable of major adverse cardiovascular events (MACE) up to 1, 5, and 10 years from the index cas
研究概览
简要总结
The new global guidelines from the World Health Organization on air quality provide evidence of the damage that air pollution inflicts on human health at even lower concentrations than previously thought. Different studies have shown an increase in the incidence of coronary artery disease (CAD) in young people in recent decades. The main objective of this project is to study the impact of environmental pollutants on the premature manifestation of CAD from different epidemiological approaches and their impact on the evolution of these patients with a gender perspective. It is a retrospective analytical case-control study nested in a cohort of patients ≤40 years old with a clinical history of CAD including: ST-segment elevation myocardial infarction, non-ST-segment elevation acute coronary syndrome, unstable angina, stable angina or silent angina according to the international classification of diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Women and men between 18 and 40 years old with a diagnosis of coronary artery disease coded in their medical records in Galicia
排除标准
- •Not having a postal code and primary care center assigned in their medical records in Galicia
- •Inclusion Criteria:
- •Women and men between 18 and 40 years old with no diagnosis or history of CAD or other coronary disease coded in their medical records
- •Exclusion Criteria:
- •Present with non-ischemic coronary diseas.
- •Have a serious condition that affects or decreases life expectancy.
- •Do not have a postal code or primary care center assigned in their medical records in Galicia
结局指标
主要结局
To evaluate the impact of environmental pollutants on the incidence of the combined variable of major adverse cardiovascular events (MACE) up to 1, 5, and 10 years from the index cas
时间窗: 15 years
To evaluate the impact of environmental pollutants on the incidence of the combined variable of major adverse cardiovascular events (MACE) up to 1, 5, and 10 years from the index cas
To determine the differences in exposure to environmental pollutants in patients ≤40 years old with and without coronary artery disease
时间窗: 15 years
The study will measure the levels of environmental pollutants (such as PM2.5, PM10, nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3), among others) in patients ≤40 years old with a clinical diagnosis of coronary artery disease and in patients without a diagnosis of coronary artery disease, in order to compare the differences.
To describe the prevalence of CAD in patients ≤40 years old in Galicia
时间窗: 15 years
To describe the prevalence of CAD in patients ≤40 years old in Galicia
次要结局
- To determine the correlation of noise pollution with premature CAD by age and sex.(15 years)
- To identify the impact of temperatures on early CAD by age and sex.(15 years)
- To compare the effect of environmental pollutants and their relationship with CAD between men and women.(15 years)
- To evaluate the influence of PM2.5 and PM10 particles on the early manifestation of CAD.(15 years)
- To evaluate the incidence of serious adverse events(15 years)
- To determine the correlation of environmental pollutants in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA).(15 years)
- To describe the prevalence of ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), benzene (C6H6), carbon monoxide (CO), and heavy metals such as arsenic, cadmium, nickel, and lead in the premature manifestation of CAD.(15 years)
研究者
pablo Juan-Salvadores
Principal Investigator
Fundacin Biomedica Galicia Sur