How Improvement in Control of Diabetes Influences the Production of a Hormone Produced in the Gut Which Improves the Release and Action of Insulin.

Not Applicable

Completed

• Conditions: Type 2 Diabetes Mellitus
• Interventions: Drug: Glimepiride; Drug: Sitagliptin

• Registration Number: NCT00747383
• Lead Sponsor: The Royal Bournemouth Hospital

Brief Summary

The study is aimed at Type 2 Diabetics who are taking Metformin, but whose Diabetes remains poorly controlled. There are two additional medications already in use, Glimepiride and Sitagliptin will be compared to assess levels of improvement in Diabetes control.

Detailed Description

Not available

Study Timeline

• Status Verified: 2008-09
• Study Start: 2008-09
• Study First Submitted: 2008-09-04
• Study First Submitted QC: 2008-09-04
• Study First Posted: 2008-09-05
• Primary Completion: 2010-09
• Study Completion: 2010-09
• Last Update Submitted: 2012-12-04
• Last Update Posted: 2012-12-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

• Diabetes Mellitus
• Currently on Metformin but poor glycaemic control,

Exclusion Criteria

• Under 18 years of age

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Glimepiride	-
2	Sitagliptin	-

Primary Outcome Measures

Name	Time	Method
Comparison of GLP-1 response at baseline and after 3 months treatment of both groups.	2 years

Trial Locations

Locations (1)

Royal Bournemouth Hospital; 🇬🇧 Bournemouth, Dorset, United Kingdom