The Efficacy of Progesterone in Treatment of Traumatic Optic Neuropathy.
- Conditions
- Traumatic optic neuropathy
- Registration Number
- TCTR20151118001
- Lead Sponsor
- Phramongkutkloa college of medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
1.Male or female patient, aged 18-65 years old.
2.Diagnosed with indirect traumatic optic neuropathy within 7 days
3.No other ocular or visual pathway effecting visual function
1.Low level of consciousness and unable to evaluated visual acuity
2.Other system injury such as cardiovascular, pulmonary injury
3.Progesterone administration within 30 days
4.Contraindicated to progesterone as following
1)Pregnancy or lactation
2)Abnormal vaginal bleeding
3)Breast mass or history of breast cancer
4)Uncontrolled blood pressure >180/110 mmHg.
5)Diabetes mellitus with complications
6)Diagnosed or history of ischemic heart disease
7)Occlusive vascular diseases
8)Active viral hepatitis, cirrhosis, liver cancer
9)Coagulopathy, deep vein thrombosis, pulmonary embolism
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Visual acuity Baseline, 1wk, 1mo, 3mo ETDRS chart
- Secondary Outcome Measures
Name Time Method Color vision, visual field testing Baseline, 1wk, 1mo, 3mo Ishihara test, Humphrey automated perimetry