Progesterone therapy effectiveness in treatment of intractable catamenial epilepsy
- Conditions
- Epilepsy.Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
- Registration Number
- IRCT201202128660N1
- Lead Sponsor
- Research Department, Medical school, Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 38
1- The women between 18 and 45 years of age who had clinically and electrographically documented refractory CPS or SGMS of temporal lobe origin; 2- All the women with demonstrated catamenial pattern of seizure exacerbation premenstrually between days 25 and 2 or during the entire luteal phase of the menstrual cycle between days 2 and 10; 3- The women with seizure exacerbation during the entire luteal phase with inadequate luteal phase cycles as documented by low serum progesterone levels less than 5 ng/ml during the mid-luteal phase; 5- The women who had premenstrual exacerbations with normal mid-luteal phase progesterone levels; 6- No pregnant and not lactating women who had no amenorrhea or had taken no major tranquilizers, antidepressant medications or OCP during 3 month prior to participate. Exclusion criteria: 1- Immigration; 2- Inaccessibility; 3- Giving up the participation; 4- Sever progesterone complications.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Seizure frequency. Timepoint: 3 months. Method of measurement: questionnaire.
- Secondary Outcome Measures
Name Time Method Seizure frequencies per month. Timepoint: 1 month. Method of measurement: questionnaire.